The combination of an experienced team of creative drug discovery scientists and the state-of-the-art instrumentation, provides the capabilities and innovative approaches to help improve the efficiency and translatability of in vitro pharmacological profiling.
Supporting drug discovery
Expertise in the application of molecular and cellular pharmacology techniques throughout the drug discovery process across therapeutic areas, with a long track record of success.
Targets & Therapeutic Areas
Full capabilities across disease areas, with particular track records in respiratory, oncology, metabolic disease and immunology. Pharmacology specialists in G protein coupled receptors, catalytic receptors, cytokine analysis, and enzymes, for both LMW and biologic drug formats.
Interrogation of signalling and enzyme pathways, from binding to phenotypic response, using the latest technologies. Expertise in phenotypic assays in primary cell systems relevant to disease models, with endpoints relevant to therapeutic effect.
Experience and capabilities to deliver medium throughput library screening for hit identification through to routine weekly support of lead optimisation projects.
Design and development of relevant, well controlled assays to address the key scientific questions and screening needs. Using a methodical and analytical approach we carefully control all variables and minimise assay artefacts (eg due to ligand or reagent/biosensor depletion, compound interference, time dependency).
Mechanism of Action
Our highly trained team have extensive experience in the application of theoretical models to data analysis to derive scalable descriptors of drug action, to better predict clinical efficacy.