Analytical Pharmacology

“We have extensive experience in the application of complex theoretical models to data analysis to derive scalable descriptors of drug action, to better predict clinical efficacy.”

Binding modality
Competitive, allosteric (using allosteric ternary complex (ATCM) models to quantify the cooperativity factor, α), two-step binding, avidity with bivalent ligands (e.g. antibodies), enzyme mechanisms (ordered, random, ping-pong) and enzyme inhibition profiling (tight-binding, mixed mode inhibition).
Functional efficacy
Quantification of ligand bias (eg ΔΔlogτ/KA), positive and negative allosteric action (using the operational ATCM to quantify the functional cooperativity factor, β)
Integrating the kinetics of binding and pathway activation/inactivation to build a better understanding of drug action over time. This knowledge can be invaluable in building and refining in vivo PK/PD models