“We are experts in the development and application of kinetic assays to measure the association and dissociation rates of unlabelled ligands.”
We have extensive experience of utilizing competition association assays in both radioligand and time-resolved fluorescence resonance energy transfer (TR-FRET) formats.
Assays are medium throughput (384 well), capable of performing fragment screening. We have experience on a range of target classes, including GPCRs, enzymes and protein-protein interactions.
Also watch a webinar from Prof Charlton in collaboration with BMG Labtech and Cisbio and on why and how to measure receptor kinetics in drug discovery programs: http://www.ddw-online.com/drug-discovery/p321001-webinar-the-kinetics-of-drug-receptor-binding:-why-it-is-important-and-how-we-can-measure-it.html