Our Resources
The Excellerate team has made significant contributions to analytical pharmacology, particularly in the field of binding and signalling kinetics.
Here you can access useful fact sheets from the team, as well as publications, presentations and other useful content.
Publications
22 April, 2026
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Paper
Unravelling intrinsic efficacy and ligand bias at G protein coupled receptors: A practical guide to assessing functional data; 2016
Lisa A Stott, David A Hall, Nicholas D Holliday
22 April, 2026
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Paper
Discovery, Characterization, and Structure-Based Optimization of Small-Molecule in Vitro and in Vivo Probes for Human DNA Polymerase Theta; 2022
Martin L. Stockley et al. Excellerate contributing authors: Nicholas D. Holliday, Julija Sirina, Viral Patel
22 April, 2026
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Paper
High-throughput kinetics in drug discovery; 2024
Maria Filipa Pinto, Julija Sirina, Nicholas D Holliday, Claire L McWhirter
22 April, 2026
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Paper
Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2; 2023
Bianca Maria Casella, James P. Farmer, Desislava N. Nesheva, Huw E. L. Williams, Steven J. Charlton, Nicholas D. Holliday, Charles A. Laughton, Shailesh N. Mistry
22 April, 2026
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Paper
GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity; 2025
Aikaterini Motso et al. Excellerate contributing authors: Leigh A. Stoddart, Nicholas D. Holliday
22 April, 2026
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Paper
Phenotypic pharmacology of novel Complex I inhibitors eliciting tissue repair concurrent to control of inflammation; 2025
Lisa Patel, Fatima Garcia-Raposo, Benjamin Moore, James Wood, Lily Morley, David Loczenski, Stephen A. Smith, Puneeta Nath, Nicholas Holliday, Sam Williams, Iain R. Greig, Paul Vink, Martyn L. Foster
22 April, 2026
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Paper
An industrial perspective on ligand bias in GPCR drug discovery; 2025
James P. Farmer, James E. Mason, Nicholas D. Holliday, Stephen J. Briddon, Leigh A. Stoddart
11 January, 2025
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Paper
Micro-pharmacokinetics: Qualifying local drug concentration at live cell membranes; 2018
Karolina Gherbi, Stephen J Briddon, Steven J Charlton
11 January, 2025
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Paper
Airway remodeling disease: primary human structural cells and phenotypic and pathway assays to identify targets with potential to prevent or reverse remodeling; 2018
Elizabeth M Rosethorne, Steven J Charlton
11 January, 2025
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Paper
Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors; 2017
David A Sykes, Holly Moore, Lisa Stott, Nicholas Holliday, Jonathan A Javitch, J Robert Lane, Steven J Charton
11 January, 2025
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Paper
GPCRs – Structure, Function and Drug Discovery; 2019
Chapter: “Kinetics of ligand binding and signalling”
Webinars
22 April, 2026
Watch Webinar
Kinetics in preclinical pharmacology – Nick Holliday, BMG spotlight; 2024 ELRIG
11 January, 2025
Watch Webinar
The kinetics of drug binding – Prof Steven Charlton; 2016, BMG Labtech
11 January, 2025
Watch Webinar
Putting the dynamics into compound profiling: using kinetic assays to shape drug discovery; 2024, SPT Labtech
Fact sheets
Posters
22 April, 2026
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Kinetic phenotyping of monocyte-to-macrophage differentiation using quantitative phase imaging ptychography; 2024
James Wood, Benjamin J.R. Moore, Lily Morley, Meetal Jotangia, Richard Woolley, Martin Humphry, Nicholas D. Holliday
22 April, 2026
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Kinetic phenotyping of cellular morphology, proliferation and motility using quantitative phase imaging ptychography; 2022
Benjamin J.R. Moore, Fatima Garcia-Raposo, Jessica Rickman, Richard Woolley, Martin Humphry, Nicholas D. Holliday. Presented at ELRIG Drug Discovery
22 April, 2026
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A Luciferase Complementation Approach to Measure GRK2 Recruitment to GPCRs; 2022
Mohammed Azim Miah, Julija Sirina, Nicholas D Holliday, Leigh A Stoddart. Presented at ELRIG Drug Discovery
22 April, 2026
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Integrating Signaling Kinetics into GPCR Compound Profiling; 2022
Leigh A Stoddart, Julija Sirina, Nicola C Dijon, Nicholas D Holliday. Presented at ELRIG Drug Discovery
11 January, 2025
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Antagonist binding kinetics at the human D1 dopamine receptor determined by HTRF assay; 2019
Kathy Sengmany, Ka-Wing Wong, Steven J Charlton, Nicholas Holliday. Presented at ELRIG Drug Discovery and the British Pharmacology Society
