Publication in The Journal of Pharmacology and Experimental Therapeutics: Novel Mitochondrial Modulation

Excellerate Bioscience are proud to have supported a recent publication in The Journal of Pharmacology and Experimental Therapeutics. 

The research highlights a novel class of developmental drugs developed by Istesso that uniquely modulate mitochondrial dynamics.

Our pharmacology team supported early mechanistic validation work, generating high-quality in vitro datasets exploring the mechanism of action in mitochondrial metabolism modulation including:

• Kinetic mitochondrial and cellular/metabolic activity assessments using human primary immune and fibroblastic cell models.
• Detailed mechanistic in vitro assays providing evidence of mitochondrial Complex I modulation and downstream signalling effects in proliferation, differentiation, adaptation and metabolite quantification.
• Functional bioenergetic profiling to assess compound impact on mitochondrial respiration, membrane potential and ROS generation.

This work builds on Excellerate’s expertise in complex cellular models and mitochondrial activity screening.

Paper Link: JPET, DOI: 10.1124/jpet.124.001838

If you are interested in how our expertise in pharmacology, metabolism and mechanism of action studies can strengthen your discovery programmes, please get in touch.